David D, Kutcher G S, Jackson E I, Mellman T A
University of Miami, Department of Psychiatry and Behavioral Sciences, and the Miami Veterans Affairs Medical Center, Fla 33136, USA.
J Clin Psychiatry. 1999 Jan;60(1):29-32. doi: 10.4088/jcp.v60n0106.
Posttraumatic stress disorder (PTSD) is known often to be comorbid with other anxiety, mood, and substance use disorders. Psychotic symptoms have also been noted in PTSD and have been reported to be more common in Hispanic veterans. However, the occurrence of psychotic symptoms, including the degree to which they are accounted for by comorbid disorders, have received limited systematic investigation. Our study objectives were to assess psychotic symptoms according to DSM-III-R criteria in patients with a primary diagnosis of combat-related PTSD and determine the associations of those symptoms with psychiatric comorbidity and ethnicity.
Fifty-three male combat veterans consecutively admitted to a PTSD rehabilitation unit were assessed for psychotic symptoms and Axis I disorders. Ninety-one percent were Vietnam veterans; 72% were white, 17% were Hispanic, and 11% were black. Associations between psychotic symptoms and comorbid depression, substance use disorders, and minority status were compared by chi-square analyses; associations between psychotic symptoms and both PTSD and dissociative symptom severity were compared by t test analysis.
Forty percent of patients reported a psychotic symptom or symptoms in the preceding 6 months. These symptoms featured auditory hallucinations in all but 1 case. The psychotic symptoms typically reflected combat-themes and guilt, were nonbizarre, and were not usually associated with formal thought disorder or flat or inappropriate affect. Psychotic symptoms were significantly associated with current major depression (p < .02), but not with alcohol or drug abuse or with self-rated PTSD and dissociation severity. Psychotic symptoms and current major depression were more common in minority (black and Hispanic) than white veterans (p < .002).
Psychotic symptoms can be a feature of combat-related PTSD and appear to be associated with major depression. The association with minority status may be a function of comorbidity.
创伤后应激障碍(PTSD)常与其他焦虑、情绪及物质使用障碍共病。PTSD患者中也有精神病性症状的记录,且据报道在西班牙裔退伍军人中更为常见。然而,包括共病障碍对其解释程度在内的精神病性症状的发生情况,尚未得到充分的系统研究。我们的研究目的是根据DSM-III-R标准评估初诊为与战斗相关PTSD的患者的精神病性症状,并确定这些症状与精神共病及种族的关联。
对连续入住PTSD康复单元的53名男性战斗退伍军人进行精神病性症状和轴I障碍评估。91%为越战退伍军人;72%为白人,17%为西班牙裔,11%为黑人。通过卡方分析比较精神病性症状与共病抑郁、物质使用障碍及少数族裔身份之间的关联;通过t检验分析比较精神病性症状与PTSD及解离症状严重程度之间的关联。
40%的患者报告在过去6个月内有一个或多个精神病性症状。除1例患者外,这些症状均为幻听。精神病性症状通常反映战斗主题和内疚感,不怪异,通常不伴有形式思维障碍或情感平淡或不恰当。精神病性症状与当前重度抑郁显著相关(p < .02),但与酒精或药物滥用、自评PTSD及解离严重程度无关。少数族裔(黑人和西班牙裔)退伍军人的精神病性症状及当前重度抑郁比白人退伍军人更常见(p < .002)。
精神病性症状可能是与战斗相关PTSD的一个特征,且似乎与重度抑郁有关。与少数族裔身份的关联可能是共病的作用。