Jacques P F, Rosenberg I H, Rogers G, Selhub J, Bowman B A, Gunter E W, Wright J D, Johnson C L
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Am J Clin Nutr. 1999 Mar;69(3):482-9. doi: 10.1093/ajcn/69.3.482.
The elevation of circulating total homocysteine concentrations in a fasting state is associated with an increased risk of occlusive vascular disease.
The primary goals of this study were to describe the distribution of serum total homocysteine concentrations in the United States and to test for differences in homocysteine concentrations among sex, age, and race-ethnicity categories.
Using surplus sera from phase 2 of the third National Health and Nutrition Examination Survey, we measured serum total homocysteine concentrations for a nationally representative sample of 3766 males and 4819 females aged > or = 12 y.
Age-adjusted geometric mean total homocysteine concentrations were 9.6 and 7.9 mmol/L in non-Hispanic white males and females, 9.8 and 8.2 mmol/L in non-Hispanic black males and females, and 9.4 and 7.4 mmol/L in Mexican American males and females, respectively. Age-adjusted geometric mean total homocysteine concentrations were significantly lower in females than in males in each race-ethnicity group (P < 0.01) and were significantly lower in Mexican American females than in non-Hispanic white and non-Hispanic black females (P < 0.01). There was a significant age-sex interaction (P < 0.01), reflecting the fact that homocysteine concentrations in females tended to diverge from those in males at younger ages and converge with those in males at older ages.
The first data on homocysteine concentrations in a nationally representative sample of Americans confirm the age and sex differences reported previously in nonrepresentative samples. These data also indicate that differences between Mexican American and non-Hispanic females may influence circulating homocysteine concentrations.
空腹状态下循环总同型半胱氨酸浓度升高与闭塞性血管疾病风险增加相关。
本研究的主要目的是描述美国血清总同型半胱氨酸浓度的分布情况，并检测性别、年龄和种族/民族类别之间同型半胱氨酸浓度的差异。
利用第三次全国健康与营养检查调查第二阶段剩余的血清，我们对3766名年龄≥12岁的男性和4819名年龄≥12岁的女性进行了血清总同型半胱氨酸浓度测量，这些样本具有全国代表性。
年龄调整后的几何平均总同型半胱氨酸浓度在非西班牙裔白人男性和女性中分别为9.6和7.9 mmol/L，在非西班牙裔黑人男性和女性中分别为9.8和8.2 mmol/L，在墨西哥裔美国男性和女性中分别为9.4和7.4 mmol/L。在每个种族/民族组中，年龄调整后的几何平均总同型半胱氨酸浓度女性均显著低于男性（P<0.01），且墨西哥裔美国女性显著低于非西班牙裔白人和非西班牙裔黑人女性（P<0.01）。存在显著的年龄-性别交互作用（P<0.01），这反映出女性同型半胱氨酸浓度在较年轻时往往与男性不同，而在较年长时与男性趋于一致。
关于美国具有全国代表性样本的同型半胱氨酸浓度的首批数据证实了先前在非代表性样本中报道的年龄和性别差异。这些数据还表明，墨西哥裔美国女性与非西班牙裔女性之间的差异可能会影响循环同型半胱氨酸浓度。
