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美国血铅水平的下降。国家健康与营养检查调查(NHANES)。

The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES).

作者信息

Pirkle J L, Brody D J, Gunter E W, Kramer R A, Paschal D C, Flegal K M, Matte T D

机构信息

Division of Environmental Health Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30333.

出版信息

JAMA. 1994 Jul 27;272(4):284-91.

PMID:8028141
Abstract

OBJECTIVE

To describe trends in blood lead levels for the US population and selected population subgroups during the time period between 1976 and 1991.

DESIGN

Two nationally representative cross-sectional surveys and one cross-sectional survey representing Mexican Americans in the southwestern United States.

SETTING/PARTICIPANTS: Participants in two national surveys that included blood lead measurements: the second National Health and Nutrition Examination Survey, 1976 to 1980 (n = 9832), and phase 1 of the third National Health and Nutrition Examination Survey, 1988 to 1991 (n = 12,119). Also, Mexican Americans participating in the Hispanic Health and Nutrition Examination Survey, 1982 to 1984 (n = 5682).

RESULTS

The mean blood lead level of persons aged 1 to 74 years dropped 78%, from 0.62 to 0.14 mumol/L (12.8 to 2.8 micrograms/dL). Mean blood lead levels of children aged 1 to 5 years declined 77% (0.66 to 0.15 mumol/L [13.7 to 3.2 micrograms/dL]) for non-Hispanic white children and 72% (0.97 to 0.27 mumol/L [20.2 to 5.6 micrograms/dL]) for non-Hispanic black children. The prevalence of blood lead levels 0.48 mumol/L (10 micrograms/dL) or greater for children aged 1 to 5 years declined from 85.0% to 5.5% for non-Hispanic white children and from 97.7% to 20.6% for non-Hispanic black children. Similar declines were found in population subgroups defined by age, sex, race/ethnicity, income level, and urban status. Mexican Americans also showed similar declines in blood lead levels of a slightly smaller magnitude over a shorter time.

CONCLUSIONS

The results demonstrate a substantial decline in blood lead levels of the entire US population and within selected subgroups of the population. The major cause of the observed decline in blood lead levels is most likely the removal of 99.8% of lead from gasoline and the removal of lead from soldered cans. Although these data indicate major progress in reducing lead exposure, they also show that the same sociodemographic factors continue to be associated with higher blood lead levels, including younger age, male sex, non-Hispanic black race/ethnicity, and low income level. Future efforts to remove other lead sources (eg, paint, dust, and soil) are needed but will be more difficult than removing lead from gasoline and soldered cans.

摘要

目的

描述1976年至1991年期间美国总体人群及部分特定人群亚组的血铅水平变化趋势。

设计

两项具有全国代表性的横断面调查以及一项代表美国西南部墨西哥裔美国人的横断面调查。

地点/参与者:两项包含血铅测量的全国性调查的参与者:1976年至1980年的第二次全国健康与营养检查调查(n = 9832),以及1988年至1991年第三次全国健康与营养检查调查的第一阶段(n = 12119)。此外,还有参与1982年至1984年西班牙裔健康与营养检查调查的墨西哥裔美国人(n = 5682)。

结果

1至74岁人群的平均血铅水平下降了78%,从0.62微摩尔/升降至0.14微摩尔/升(12.8微克/分升降至2.8微克/分升)。1至5岁非西班牙裔白人儿童的平均血铅水平下降了77%(从0.66微摩尔/升降至0.15微摩尔/升[13.7微克/分升降至3.2微克/分升]),1至5岁非西班牙裔黑人儿童的平均血铅水平下降了72%(从0.97微摩尔/升降至0.27微摩尔/升[20.2微克/分升降至5.6微克/分升])。1至5岁儿童血铅水平达到或高于0.48微摩尔/升(10微克/分升)的患病率,非西班牙裔白人儿童从85.0%降至5.5%,非西班牙裔黑人儿童从97.7%降至20.6%。在按年龄、性别、种族/族裔、收入水平和城市状况划分出的人群亚组中也发现了类似的下降情况。墨西哥裔美国人的血铅水平在较短时间内也出现了幅度稍小的类似下降。

结论

结果表明美国总体人群以及部分特定人群亚组的血铅水平大幅下降。血铅水平下降的主要原因很可能是汽油中99.8%的铅被去除以及焊锡罐中的铅被去除。尽管这些数据表明在减少铅暴露方面取得了重大进展,但也显示相同的社会人口学因素仍然与较高的血铅水平相关,包括年龄较小、男性、非西班牙裔黑人种族/族裔以及低收入水平。未来需要努力消除其他铅源(如油漆、灰尘和土壤),但这将比从汽油和焊锡罐中去除铅更加困难。

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