Lai H C, Corey M, FitzSimmons S, Kosorok M R, Farrell P M
Department of Pediatrics, University of Wisconsin School of Medicine, Madison 53792, USA.
Am J Clin Nutr. 1999 Mar;69(3):531-8. doi: 10.1093/ajcn/69.3.531.
Differences in growth status of patients with cystic fibrosis (CF) between the United States and Canada were reported in the 1980s based on analysis of data from 2 regional CF centers.
We evaluated the current growth status of the entire CF population in the United States and Canada in view of recent advances in the treatment of CF.
Growth data from the 1992-1994 CF Patient Registries were analyzed.
Mean height and weight were at approximately the 30th percentile for children with CF in the United States. Mean height and weight were 4-5 percentiles higher in children with CF in Canada than in those in the United States (P < 0.01), but percentages of ideal weight (104%) were similar in both populations. In adults with CF, mean height was similar at the 37th percentile; however, weight (26th compared with the 21st percentiles) and percentage of ideal weight (93% compared with 90%) were significantly higher in Canada than in the United States. Differences related to sex and age were similar in both countries for all indexes, which showed a high prevalence of underweight in infants and in older patients, but little sex discrepancy.
We observed substantially smaller differences in the growth indexes of CF patients between the United States and Canada compared with results from the 1980s. These findings reflect significant improvements in the nutritional status of US patients in recent years. However, caution is required in the direct comparison of mean percentiles from reports using different growth standards because there are systematic differences in growth standards, which affect, in particular, the comparison of growth in males and females.
20世纪80年代，基于对两个地区囊性纤维化（CF）中心数据的分析，报告了美国和加拿大CF患者生长状况的差异。
鉴于CF治疗的最新进展，我们评估了美国和加拿大全体CF患者的当前生长状况。
分析了1992 - 1994年CF患者登记处的生长数据。
美国CF儿童的平均身高和体重约处于第30百分位。加拿大CF儿童的平均身高和体重比美国儿童高4 - 5个百分位（P < 0.01），但两国理想体重百分比（104%）相似。在成年CF患者中，平均身高相似，处于第37百分位；然而，加拿大的体重（第26百分位与第21百分位相比）和理想体重百分比（93%与90%相比）显著高于美国。两国所有指标的性别和年龄差异相似，婴儿和老年患者体重过轻的患病率较高，但性别差异不大。
与20世纪80年代的结果相比，我们观察到美国和加拿大CF患者生长指标的差异显著减小。这些发现反映了近年来美国患者营养状况的显著改善。然而，在直接比较使用不同生长标准的报告中的平均百分位数时需要谨慎，因为生长标准存在系统差异，这尤其影响男女生长情况的比较。
