Hsieh J C, Stone-Elander S, Ingvar M
Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska Hospital/Institute, Stockholm, Sweden.
Neurosci Lett. 1999 Feb 26;262(1):61-4. doi: 10.1016/s0304-3940(99)00060-9.
We used positron emission tomography (PET) to monitor the regional cerebral blood flow (rCBF) as an index of brain activity in regions proposed to participate in affective-motivational and cognitive-evaluative dimensions of pain during anticipation of a noxious stimulation. Specifically we were interested in the anterior cingulate cortex (ACC), the ventromedial prefrontal cortex (VMPFC) and the periaqueductal grey (PAG). Anticipating an unpredictable and unlearned pain stimulus activated the right ACC, the VMPFC and the PAG while anticipating a learned pain-stimulus resulted in a decreased activity in the ACC and the VMPFC. These patterns are compatible with two facets of affect-laden cognitive coping: alertness and attention-distraction. The right-preponderant expression of the changes in the ACC supports the hypothesis of a preferential role of the non-dominant hemisphere in negative emotional processing. The data demonstrate an anticipatory coping mechanism and illustrate a neurophysiological process underlying the modulation of attention to pain.
我们使用正电子发射断层扫描（PET）来监测局部脑血流量（rCBF），以此作为在预期有害刺激期间参与疼痛的情感动机和认知评估维度的脑区活动指标。具体而言，我们关注前扣带回皮质（ACC）、腹内侧前额叶皮质（VMPFC）和导水管周围灰质（PAG）。预期不可预测且未习得的疼痛刺激会激活右侧ACC、VMPFC和PAG，而预期已习得的疼痛刺激则会导致ACC和VMPFC的活动减少。这些模式与充满情感的认知应对的两个方面相符：警觉和注意力分散。ACC变化的右侧优势表达支持了非优势半球在负性情绪加工中起优先作用的假说。数据表明了一种预期应对机制，并阐明了调节对疼痛注意力的神经生理过程。
