Rainville P, Duncan G H, Price D D, Carrier B, Bushnell M C
D-epartement de Psychologie and Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montréal, Québec, Canada H3C 3J7.
Science. 1997 Aug 15;277(5328):968-71. doi: 10.1126/science.277.5328.968.
Recent evidence demonstrating multiple regions of human cerebral cortex activated by pain has prompted speculation about their individual contributions to this complex experience. To differentiate cortical areas involved in pain affect, hypnotic suggestions were used to alter selectively the unpleasantness of noxious stimuli, without changing the perceived intensity. Positron emission tomography revealed significant changes in pain-evoked activity within anterior cingulate cortex, consistent with the encoding of perceived unpleasantness, whereas primary somatosensory cortex activation was unaltered. These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies.
最近有证据表明，人类大脑皮层的多个区域会被疼痛激活，这引发了人们对这些区域在这种复杂体验中各自作用的猜测。为了区分参与疼痛情感的皮层区域，采用催眠暗示来选择性地改变有害刺激的不适感，同时不改变所感知到的强度。正电子发射断层扫描显示，前扣带回皮层内疼痛诱发活动有显著变化，这与所感知到的不适感的编码一致，而初级躯体感觉皮层的激活则未改变。这些发现为人类提供了直接的实验证据，将额叶边缘系统活动与疼痛情感联系起来，这与早期临床病变研究最初的推测一致。
