Komiya S, Zenmyo M, Inoue A
Department of Orthopedic Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Arch Orthop Trauma Surg. 1999;119(1-2):22-9. doi: 10.1007/s004020050349.
Among 56 cases of a giant cell tumor of bone (GCT) and 52 cases of chondrosarcoma (CSA) in our series, four patients were discovered to have a tumor in the pelvic bone that grew in size during pregnancy. These four rare cases are described here. They include three cases of a GCT in the sacrum and one case of a CSA in the innominate bone. The dextran-coated charcoal assay and immunohistochemical techniques demonstrated the independence of these tumors from hormonal regulation despite the growth stimulated during pregnancy. It was concluded that the delay in detection of these tumors in the pelvis was just related to the opportunity afforded for unexpected growth during pregnancy. Surgical management was difficult due to the delay in tumor detection. The initial complaints such as pain, discomfort, or numbness around the pelvis were misinterpreted as symptoms of pregnancy. It should be kept in mind that during pregnancy, any pain or numbness in the pelvic region could be the direct result of a tumor in the pelvic bone.
在我们收集的56例骨巨细胞瘤（GCT）和52例软骨肉瘤（CSA）病例中，发现有4例患者的盆腔骨肿瘤在孕期增大。在此描述这4例罕见病例。其中包括3例骶骨骨巨细胞瘤和1例无名骨软骨肉瘤。葡聚糖包被活性炭测定法和免疫组化技术表明，尽管孕期肿瘤生长受到刺激，但这些肿瘤不受激素调节影响。得出的结论是，这些盆腔肿瘤检测延迟仅仅与孕期出现意外生长的机会有关。由于肿瘤检测延迟，手术治疗存在困难。最初出现的诸如骨盆周围疼痛、不适或麻木等主诉被误解为妊娠症状。应当牢记，孕期盆腔区域的任何疼痛或麻木都可能是盆腔骨肿瘤的直接结果。
