Pawluk R S, Tummala S, Brown J J, Borrello J A
Mallinckrodt Institute of Radiology, Washington University Medical Center, St. Louis, Missouri 63110, USA.
J Magn Reson Imaging. 1999 Feb;9(2):266-73. doi: 10.1002/(sici)1522-2586(199902)9:2<266::aid-jmri17>3.0.co;2-7.
The aim of this study was to determine the relative ability of T2-weighted and dynamic gadolinium-enhanced T1-weighted gradient-echo sequences to detect and characterize focal hepatic lesions. We retrospectively studied 37 patients with proven focal hepatic lesions using the following sequences: a T1-weighted spin-echo sequence (T1), a T2-weighted sequence (T2), and a series of breath-hold dynamic gadolinium-enhanced T1-weighted gradient-echo sequences (Gd). Two observers were asked to determine retrospectively the number and type of focal hepatic lesions present using images from three combinations of sequences (T1+T2, T1+Gd, T1+T2+Gd). Proof of the number and diagnosis of focal lesions in each patient was established using a consensus read. Both readers detected more focal lesions when both the T2-weighted sequences and the gadolinium-enhanced sequences were available than on either sequence alone, although this improvement reached statistical significance (P<0.05) only for one of the readers. There was no significant difference (P<0.05) in the ability to characterize lesions between any of the sets of sequences. The combination of dynamic gadolinium-enhanced images and T2-weighted images was shown to assess focal hepatic lesions better than either of these sequences alone.
本研究的目的是确定T2加权和动态钆增强T1加权梯度回波序列检测和鉴别肝脏局灶性病变的相对能力。我们回顾性研究了37例经证实患有肝脏局灶性病变的患者，使用了以下序列：T1加权自旋回波序列（T1）、T2加权序列（T2）以及一系列屏气动态钆增强T1加权梯度回波序列（Gd）。要求两名观察者回顾性地根据三种序列组合（T1+T2、T1+Gd、T1+T2+Gd）的图像确定肝脏局灶性病变的数量和类型。通过共识解读确定每位患者局灶性病变的数量和诊断。当T2加权序列和钆增强序列都可用时，两位观察者检测到的局灶性病变均多于单独使用任一序列时，尽管这种改善仅对其中一位观察者达到统计学意义（P<0.05）。在任何一组序列之间，鉴别病变的能力均无显著差异（P<0.05）。结果表明，动态钆增强图像和T2加权图像的组合评估肝脏局灶性病变的效果优于单独使用这两种序列中的任何一种。
