Szekeres L, Borbola J, Papp J G
Acta Biol Med Ger. 1976;35(8-9):1119-26.
The cardiac actions of arachidonic acid (AA, C 20:4), the precursor of prostaglandin E2 (PGE2) and F2 alpha (PGF2 alpha) were studied in isolated atria and papillary muscles of guniea-pigs as well as canine Purkinje fibers. In contrast to the cardio-depressant actions of some short and long-chain fatty acids (octanoate, oleate) AA (10(-6)-10(-4) M) increased sinoatrial rate and contractility in guinea-pig atrial preparations. This cardio-stimulant action of AA was accompanied by an increase in the amplitude and maximum rate of rise of the intracellularly recorded atrial action potential. Some increase in the resting membrane potential and a slight prolongation of the action potential duration could also be observed. AA did not induce any pace-maker activity in isolated papillary muscle of guinea pigs or in isolated Purkinje fibers. Similarly to AA, PGE2 and PGF2 alpha (2.1-10(-8)12.1-10(-5) M) were also found to increase atrial rate and contractile force. The stimulating actions of AA were reduced by application of high concentrations of indomethacin (5-10(-5) M).
在豚鼠离体心房和乳头肌以及犬浦肯野纤维中研究了花生四烯酸（AA，C20:4）的心脏作用，AA是前列腺素E2（PGE2）和F2α（PGF2α）的前体。与一些短链和长链脂肪酸（辛酸、油酸）的心脏抑制作用相反，AA（10⁻⁶ - 10⁻⁴ M）可增加豚鼠心房标本的窦房结频率和收缩力。AA的这种心脏刺激作用伴随着细胞内记录的心房动作电位的幅度和最大上升速率的增加。还可观察到静息膜电位略有增加，动作电位持续时间稍有延长。AA在豚鼠离体乳头肌或离体浦肯野纤维中未诱导任何起搏活动。与AA相似，PGE2和PGF2α（2.1×10⁻⁸ - 12.1×10⁻⁵ M）也被发现可增加心房率和收缩力。高浓度消炎痛（5×10⁻⁵ M）的应用可降低AA的刺激作用。
