Harris E E, Hey J
Department of Genetics, Rutgers University, Nelson Biological Labs, 604 Allison Road, Piscataway, NJ 08854-8082, USA.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3320-4. doi: 10.1073/pnas.96.6.3320.
Diverse African and non-African samples of the X-linked PDHA1 (pyruvate dehydrogenase E1 alpha subunit) locus revealed a fixed DNA sequence difference between the two sample groups. The age of onset of population subdivision appears to be about 200 thousand years ago. This predates the earliest modern human fossils, suggesting the transformation to modern humans occurred in a subdivided population. The base of the PDHA1 gene tree is relatively ancient, with an estimated age of 1.86 million years, a late Pliocene time associated with early species of Homo. PDHA1 revealed very low variation among non-Africans, but in other respects the data are consistent with reports from other X-linked and autosomal haplotype data sets. Like these other genes, but in conflict with microsatellite and mitochondrial data, PDHA1 does not show evidence of human population expansion.
对X连锁的PDHA1（丙酮酸脱氢酶E1α亚基）基因座的多种非洲和非非洲样本进行研究，发现两个样本组之间存在固定的DNA序列差异。群体分化的起始时间似乎约为20万年前。这早于最早的现代人类化石，表明向现代人类的转变发生在一个已分化的群体中。PDHA1基因树的基部相对古老，估计年龄为186万年，这是一个上新世晚期，与早期人类物种相关。PDHA1在非非洲人中显示出非常低的变异，但在其他方面，数据与其他X连锁和常染色体单倍型数据集的报告一致。与这些其他基因一样，但与微卫星和线粒体数据相矛盾的是，PDHA1没有显示出人类群体扩张的证据。
