Induction of humoral and cellular immune responses in mice by a recombinant fowlpox virus expressing the E2 protein of bovine viral diarrhea virus.
作者信息
Mehdy Elahi S, Bergeron J, Nagy E, Talbot B G, Harpin S, Shen S H, Elazhary Y
机构信息
Virology Section, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Que., Canada.
出版信息
FEMS Microbiol Lett. 1999 Feb 15;171(2):107-14. doi: 10.1111/j.1574-6968.1999.tb13419.x.
A recombinant fowlpox virus (rFPV/E2) expressing the E2 protein of bovine viral diarrhea virus (BVDV) was constructed and characterized. Mice were immunized with recombinant virus and both humoral and cellular immune responses were studied. rFPV/E2 induced BVDV-specific antibodies which were detected by ELISA. In addition, mouse sera were shown to neutralize BVDV. A cytokine ELISA assay revealed that mice vaccinated with rFPV/E2 induced 7-fold more interferon-gamma than parental fowlpox virus.
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