牛病毒性腹泻病毒的异质性及其对疫苗接种和诊断的潜在影响。
Bovine Pestivirus Heterogeneity and Its Potential Impact on Vaccination and Diagnosis.
机构信息
Virology Department, Animal and Plant Health Agency, APHA-Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB, UK.
Department of Virology, National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Puławy, Poland.
出版信息
Viruses. 2020 Oct 6;12(10):1134. doi: 10.3390/v12101134.
Abstract
Bovine Pestiviruses A and B, formerly known as bovine viral diarrhoea viruses (BVDV)-1 and 2, respectively, are important pathogens of cattle worldwide, responsible for significant economic losses. Bovine viral diarrhoea control programmes are in effect in several high-income countries but less so in low- and middle-income countries where bovine pestiviruses are not considered in disease control programmes. However, bovine pestiviruses are genetically and antigenically diverse, which affects the efficiency of the control programmes. The emergence of atypical ruminant pestiviruses (Pestivirus H or BVDV-3) from various parts of the world and the detection of Pestivirus D (border disease virus) in cattle highlights the challenge that pestiviruses continue to pose to control measures including the development of vaccines with improved cross-protective potential and enhanced diagnostics. This review examines the effect of bovine pestivirus diversity and emergence of atypical pestiviruses in disease control by vaccination and diagnosis.
摘要
牛病毒性腹泻病毒 A 和 B，以前分别被称为牛病毒性腹泻病毒 1 和 2，是全球重要的牛病原体，造成了重大的经济损失。一些高收入国家实施了牛病毒性腹泻控制计划，但在中低收入国家实施较少，因为这些国家的疾病控制计划中不考虑牛病毒性腹泻病毒。然而，牛病毒性腹泻病毒在遗传和抗原上具有多样性，这影响了控制计划的效率。来自世界不同地区的非典型反刍动物病毒性腹泻病毒（病毒 H 或牛病毒性腹泻病毒 3）的出现，以及在牛中检测到的病毒 D（边境病病毒），突出表明病毒性腹泻病毒继续对控制措施构成挑战，包括开发具有改进的交叉保护潜力和增强的诊断能力的疫苗。这篇综述检查了牛病毒性腹泻病毒的多样性和非典型病毒性腹泻病毒的出现对疫苗接种和诊断在疾病控制中的影响。
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