Holla B S, Gonsalves R
Department of P.G. Studies and Research in Chemistry, Mangalore University, Mangalagangothri.
Boll Chim Farm. 1998 Dec;137(11):467-72.
The preparation of bis-(4-amino-5-mercapto-1,2,4-triazol-3yl)alkanes is described. These bis-(amino-mercapto-triazolyl) alkanes are characterized by analytical and spectral data. They are also characterized by the preparation of the Schiff bases by condensing them with various benzaldehydes and nitro furfural diacetate in dimethyl formamide-ethanol medium in the presence of concentrated sulphuric acid. The structures of Schiff bases are assigned based on analytical and spectral data. The newly synthesized compounds are screened for their antibacterial properties against Gram-positive and Gram-negative bacteria. Most of them showed significant activity.
描述了双（4-氨基-5-巯基-1,2,4-三唑-3-基）烷烃的制备方法。这些双（氨基-巯基-三唑基）烷烃通过分析和光谱数据进行表征。它们还通过在浓硫酸存在下于二甲基甲酰胺 - 乙醇介质中与各种苯甲醛和硝基糠醛二乙酸酯缩合制备席夫碱来进行表征。席夫碱的结构根据分析和光谱数据确定。对新合成的化合物进行了针对革兰氏阳性和革兰氏阴性细菌的抗菌性能筛选。其中大多数表现出显著活性。
