Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
J Enzyme Inhib Med Chem. 2010 Oct;25(5):599-607. doi: 10.3109/14756360903257884.
A series of biologically active oxovanadium(IV) complexes of triazole derived Schiff bases L(1)-L(5) have been synthesized and characterized by their physical, analytical, and spectral data. The synthesized ligands potentially act as bidentate, in which the oxygen of furfural and nitrogen of azomethine coordinate with the oxovanadium atom to give a stoichiometry of vanadyl complexes 1:2 (M:L) in a square-pyramidal geometry. In vitro antibacterial and antifungal activities on different species of pathogenic bacteria (E. coli, S. flexneri, P. aeruginosa, S. typhi, S. aureus, and B. subtilis) and fungi (T. longifusus, C. albicans, A. flavus, M. canis, F. solani, and C. glabrata) have been studied. All compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against most of the fungal strains. The brine shrimp bioassay was also carried out to check the cytotoxicity of coordinated and uncoordinated synthesized compounds.
一系列基于三唑的席夫碱的生物活性氧钒(IV)配合物 L(1)-L(5)已被合成，并通过其物理、分析和光谱数据进行了表征。合成的配体可能作为双齿配体，其中糠醛的氧和亚甲胺的氮与氧钒原子配位，以给出四方锥几何形状的钒氧基配合物 1:2 (M:L)的化学计量比。对不同种类的致病菌（大肠杆菌、福氏志贺菌、铜绿假单胞菌、伤寒沙门氏菌、金黄色葡萄球菌和枯草芽孢杆菌）和真菌（长根菇、白念珠菌、黄曲霉、犬小孢子菌、茄病镰刀菌和光滑念珠菌）进行了体外抗菌和抗真菌活性研究。所有化合物都表现出对一种或多种细菌菌株的中度至显著的抗菌活性，并且对大多数真菌菌株具有良好的抗真菌活性。还进行了卤虫生物测定，以检查配位和未配位合成化合物的细胞毒性。
