Liu J J, Daya M R, Mann N C
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55906, USA.
J Toxicol Clin Toxicol. 1999;37(1):69-73. doi: 10.1081/clt-100102410.
Methanol poisoning accounts for several deaths annually in the province of Ontario. Our study was aimed at identifying the associated epidemiological factors for fatal outcomes following methanol poisoning in order to develop preventative strategies.
The records of the Ontario Provincial Coroner's Office were reviewed retrospectively for all poison-related, alcohol-related, and chronic alcohol use-related deaths for the period of January 1, 1986 to December 31, 1991. Age, gender, reason for ingestion (accidental or intentional), and source of methanol for each victim were recorded.
There were 43 fatalities during this period, 39 males and 4 females with a mean age of 45 years (range 18-80). Suicide attempts accounted for 21 (49%) cases while the remaining 22 (51%) deaths were classified as accidental. Fourteen (64%) of these 22 patients consumed products labeled as methyl alcohol or wood alcohol as a substitute for ethanol. In 3 cases, the accidental ingestion was the direct result of methanol being improperly stored in containers normally associated with ethanol. The remaining 5 patients were poisoned through the consumption of liquor from illicit sources.
Over half of the methanol-related deaths in Ontario are accidental and potentially preventable. Possible preventative strategies include mandatory product relabeling to eliminate the word alcohol, enhanced public education, and the addition of aversive agents to methanol-containing commercial products.
安大略省每年有几起因甲醇中毒导致的死亡事件。我们的研究旨在确定甲醇中毒后致命结局的相关流行病学因素,以便制定预防策略。
回顾性审查安大略省验尸官办公室1986年1月1日至1991年12月31日期间所有与中毒、酒精相关及慢性酒精使用相关的死亡记录。记录每个受害者的年龄、性别、摄入原因(意外或故意)以及甲醇来源。
在此期间有43例死亡,其中39例为男性,4例为女性,平均年龄45岁(范围18 - 80岁)。自杀未遂占21例(49%),其余22例(51%)死亡被归类为意外。这22例患者中有14例(64%)饮用了标有甲醇或木醇的产品以替代乙醇。3例中,意外摄入是由于甲醇被不当存放在通常与乙醇相关的容器中直接导致的。其余5例患者因饮用非法来源的酒而中毒。
安大略省超过一半的甲醇相关死亡是意外且可能可预防的。可能的预防策略包括强制产品重新贴标签以消除“酒精”一词、加强公众教育以及在含甲醇的商业产品中添加厌恶剂。