Stimulation of lower esophageal sphincter pressure (LESP) by cimetidine -- a double-blind study.

Using the rapid pull-through technique the effect of 400 mg cimetidine perorally on lower oesophageal sphincter pressure was studied in a controlled trial in 14 subjects. Cimetidine caused a significant rise of the integrated basal pressure. The response to 0.6 mug/kg pentagastrin was augmented by cimetidine whereas under atropine sulphate infusion this effect could not be demonstrated. Cimetidine may act on LESP by blocking inhibiting receptors.