Tympner F, Rösch W, Domschke W, Demling L
Acta Hepatogastroenterol (Stuttg). 1976 Nov-Dec;23(6):444-8.
Maldigestion phenomena in patients subjected to a Billroth II (B II) operation are in part attributed to an atrophy of the pancreas due to inactivity. In order to investigate this, a Lagerlöf tube was introduced under endoscopic control into the afferent loop, and the function of the exocrine pancreas studied after endogenous and exogenous stimulation. During endogenous stimulation of the exocrine pancreas by means of a Lundh test meal, no significant differences in the secretory pattern of the Billroth II patients as compared with healthy test subjects were found. In contrast, during exogenous stimulation, the output of trypsin and chymotrypsin in healthy subjects was significantly greater than in the B II patients. Since, in comparison with maximal stimulation, the endogenous secretin released by the jejunal mucosa in response to the intake of food, effects only approximately 25% of the bicarbonate production and endogenous pancreozymin effects some 50% of the enzyme output, the maldigestion phenomena observed in B II patients are inpart understandable.
接受毕罗Ⅱ式（BⅡ）手术的患者出现消化功能不良现象，部分原因是胰腺因不活动而萎缩。为了对此进行研究，在内镜控制下将拉格洛夫管插入输入袢，并在内源性和外源性刺激后研究外分泌胰腺的功能。在内源性刺激外分泌胰腺时，通过伦德试验餐进行，结果发现毕罗Ⅱ式手术患者的分泌模式与健康受试对象相比无显著差异。相比之下，在外源性刺激期间，健康受试者的胰蛋白酶和糜蛋白酶分泌量明显高于毕罗Ⅱ式手术患者。由于与最大刺激相比，空肠黏膜因摄入食物而释放的内源性促胰液素仅影响约25%的碳酸氢盐生成，内源性促胰酶素影响约50%的酶分泌量，因此毕罗Ⅱ式手术患者中观察到的消化功能不良现象在一定程度上是可以理解的。
