Lee S P, Lai K S
Am J Gastroenterol. 1976 Mar;65(3):244-8.
Exocrine pancreatic function was assessed by the standard test meal method of Lundh in a control group, and 13 patients with nonalcoholic, postnecrotic cirrhosis of the liver. In six of these patients, splenorenal shunts were performed and exocrine pancreatic function was assessed before and three months after operation. In three of the six, the secretin-pancreozymin stimulation test was also performed. An increased volume but normal trypsin output was observed in the unoperated cirrhotic patients. An increase both in volume and in trypsin was found in the cirrhotic patients after shunting using the test meal stimulation. There was no appreciable difference, however, when tested with secretin and pancreozymin. Hypersecretion in cirrhotics, with or without shunts, is probably due to a by-pass of the hepatic degradation of normal pancreatic secretogogues produced by the intestine.
采用伦德标准试餐法对一组对照组以及13例非酒精性、坏死后肝硬化患者的胰腺外分泌功能进行了评估。其中6例患者接受了脾肾分流术，并在手术前和术后三个月评估了胰腺外分泌功能。在这6例患者中的3例还进行了促胰液素-胰酶泌素刺激试验。未手术的肝硬化患者胰液分泌量增加但胰蛋白酶分泌量正常。使用试餐刺激后，分流术后的肝硬化患者胰液分泌量和胰蛋白酶分泌量均增加。然而，用促胰液素和胰酶泌素检测时，差异并不明显。无论有无分流，肝硬化患者的高分泌可能是由于肠道产生的正常胰腺促分泌素绕过了肝脏的降解过程。
