Döbrössy M D, Dunnett S B
MRC Cambridge Centre for Brain Repair and Department of Experimental Psychology, University of Cambridge, UK.
Brain Res Bull. 1998 Dec;47(6):585-93. doi: 10.1016/s0361-9230(98)00129-4.
It has been reported that homotopic neural transplants can ameliorate behavioural impairments induced by striatal lesions in a reaction time (RT) task. In the present study we seek to replicate and extend this observation in a new lateralised choice RT task based on the conventional Skinner box apparatus. Rats were trained to make rapid lateralised lever press responses to a visual stimulus presented on either the left or the right side of the animal. The RTs required to initiate and execute correct responses were recorded, along with other accuracy and performance indices. Following unilateral lesions of the dorsal striatum, the rats exhibited an increased number of error trials, a bias to respond towards the ipsilateral side, a decreased accuracy on the contralateral side, and an increase of the execution time to respond correctly to contralateral stimuli. Striatal grafts alleviated the lateralised response deficits, prevented the development of lateral disparity, and restored the speed of responding back to pre-lesion levels. Control grafts of cortical tissues also increased task accuracy and reduced the ipsilateral bias in responding, but were without effect on the RT deficit.
据报道，在反应时间（RT）任务中，同位神经移植可以改善纹状体损伤引起的行为障碍。在本研究中，我们试图在基于传统斯金纳箱装置的新的侧向选择RT任务中复制并扩展这一观察结果。训练大鼠对出现在动物左侧或右侧的视觉刺激做出快速的侧向杠杆按压反应。记录启动和执行正确反应所需的反应时间，以及其他准确性和表现指标。在背侧纹状体单侧损伤后，大鼠出现错误试验次数增加、向同侧反应的偏向、对侧准确性降低以及对侧刺激正确反应的执行时间增加。纹状体移植减轻了侧向反应缺陷，防止了侧向差异的发展，并将反应速度恢复到损伤前水平。皮质组织的对照移植也提高了任务准确性并减少了反应中的同侧偏向，但对反应时间缺陷没有影响。
