Sinzinger H, Wicke L, Willvonseder R, Feigl W, Hernuss P, Müller-Tyl E, Erd W
Acta Morphol Neerl Scand. 1976 Sep;14(3):201-14.
The arterial wall (abdominal aorta, splenic artery) has been investigated after irradiation with 3000 rad (3 X 1000 rad within 3 weeks) in rabbits. In addition to light microscopic techniques semi-thin sections, electron microscopic sections, permeability staining and autoradiographic techniques have been applied. These studies revealed typical lesions in the media (elastic degeneration, cellular proliferation of the smooth muscle cells) and lesions of the endothelial cells using ultrastructural techniques especially. The intima showed an increasing permeability in the irradiated area, while autoradiographically a higher mitotic activity in the media was demonstrable. The results are discussed in the light of similar atherosclerotic and X-ray induced lesions of human blood vessels.
对接受3000拉德（3周内分3次，每次1000拉德）照射后的家兔动脉壁（腹主动脉、脾动脉）进行了研究。除光学显微镜技术外，还应用了半薄切片、电子显微镜切片、通透性染色和放射自显影技术。这些研究尤其通过超微结构技术揭示了中膜的典型病变（弹性退变、平滑肌细胞的细胞增殖）以及内皮细胞的病变。内膜在照射区域显示出通透性增加，而放射自显影显示中膜有更高的有丝分裂活性。根据人类血管类似的动脉粥样硬化和X射线诱导病变对结果进行了讨论。
