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[人参根及细胞培养物中含多糖生物聚合物的干扰素诱导作用]

[Interferon-inducing action of polysaccharide-containing biopolymers from ginseng root and cell culture].

作者信息

Smolina T P, Orlova T G, Shcheglovitova O N, Besednova N N

机构信息

Research Institute of Epidemiology and Microbiology, Siberian Department of the Russian Academy of Medical Sciences, Vladivostok.

出版信息

Antibiot Khimioter. 1998;43(11):21-3.

Abstract

Induction of interferon (IF) and tumor necrosis factor (TNF) under the action of two polysaccharide preparations of ginseng i.e. panaxan-1 (from ginseng root) and panaxan-2 (from ginseng cell culture) was studied. Both the preparations induced production of TNF and IF in human leukocytes. By its properties and the typing results the induced IF proved to be gamma-IF. The preparation from the ginseng cell culture in the doses used had a higher IF inducing activity which could be explained by the difference in the polysaccharide composition of the preparations.

摘要

研究了人参的两种多糖制剂即人参聚糖-1(来自人参根)和人参聚糖-2(来自人参细胞培养物)作用下干扰素(IF)和肿瘤坏死因子(TNF)的诱导情况。两种制剂均能诱导人白细胞产生TNF和IF。根据其特性和分型结果,诱导产生的IF被证明是γ-IF。人参细胞培养物来源的制剂在所使用的剂量下具有更高的IF诱导活性,这可以通过制剂中多糖组成的差异来解释。

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