Borisova N V, Kriukov V I, Kaplun A P, Shvets V I
Lomonosov Academy of Fine Chemical Technology, Moscow, Russia.
Bioorg Khim. 1998 Nov;24(11):848-55.
To increase the solubility of L-3,4-dihydroxyphenylalanine (DOPA) and dopamine (DA) incorporated in liposomes, it was suggested to convert them into ammonium and 1-adamantylammonium borate complexes. The structure of these complexes was studied by 11B and 1H NMR, IR, and mass spectrometry and conductometry. The liposomic form of the complexes is characterized by a high active compound/lipid molar ratio (0.5). Catechols in the form of complex salts are retained better within the inner volume of liposomes.
为了提高包裹在脂质体中的L-3,4-二羟基苯丙氨酸（多巴）和多巴胺（DA）的溶解度，有人建议将它们转化为铵盐和1-金刚烷基硼酸铵络合物。通过11B和1H NMR、红外光谱、质谱和电导测定法研究了这些络合物的结构。这些络合物的脂质体形式的特征是具有高活性化合物/脂质摩尔比（0.5）。络合盐形式的儿茶酚在脂质体内部体积中保留得更好。
