Borisova N V, Kaplun A P, Bogomolov O V, Grigor'ev V B, Iurasov V V, Nikushkin E V, Kryzhanovskiĭ G N, Shvets V I
Bioorg Khim. 1996 Oct-Nov;22(10-11):846-51.
L-3,4-Dihydroxyphenylalanine (DOPA) and dopamine encapsulated in liposomes have been obtained. These preparations can be used as drugs for Parkinson's disease. The level of encapsulation of the compounds under study in liposomes and their partition coefficients have been determined. The kinetics of DOPA (or dopamine) exit from the liposomes have been studied.
已获得包裹在脂质体中的L-3,4-二羟基苯丙氨酸(多巴)和多巴胺。这些制剂可用作治疗帕金森病的药物。已测定了所研究化合物在脂质体中的包封率及其分配系数。研究了多巴(或多巴胺)从脂质体中释放的动力学。