Sofuoglu M, Pentel P R, Bliss R L, Goldman A I, Hatsukami D K
Department of Psychiatry, University of Minnesota, Minneapolis 55414, USA.
Drug Alcohol Depend. 1999 Feb 1;53(3):273-5. doi: 10.1016/s0376-8716(98)00140-9.
The goal of this pilot study was to determine the effects of phenytoin on cocaine self-administration in a human laboratory model. Subjects were randomized to either phenytoin (n = 6) or placebo (n = 7). Those assigned to phenytoin treatment received a single oral loading dose of 20 mg/kg. The phenytoin and placebo treatment groups did not differ in the number of tokens valued at $5, exchanged for cocaine. Similarly, the cardiovascular and subjective response to cocaine administration did not show a statistically significant treatment effect. In this laboratory model, phenytoin did not alter either the self-administration or effects of cocaine.
这项初步研究的目的是在人体实验室模型中确定苯妥英对可卡因自我给药的影响。受试者被随机分为苯妥英组（n = 6）或安慰剂组（n = 7）。分配到苯妥英治疗组的受试者接受了20 mg/kg的单次口服负荷剂量。在用于交换可卡因的价值5美元的代币数量上，苯妥英组和安慰剂治疗组没有差异。同样，对可卡因给药的心血管和主观反应也未显示出具有统计学意义的治疗效果。在这个实验室模型中，苯妥英既没有改变可卡因的自我给药情况，也没有改变其效果。
