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本文引用的文献

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2
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Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration.皮下注射可卡因后人体血浆中可卡因的主要和次要代谢产物。
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ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes.国际抗癫痫联盟治疗指南：抗癫痫药物作为癫痫发作和综合征初始单药治疗的疗效和有效性的循证分析
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Phenytoin poisoning.苯妥英中毒。
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Pharmacological treatment of cocaine dependence: a systematic review.可卡因依赖的药物治疗：一项系统评价。
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Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity.乙醇与抗惊厥药对心血管药物修饰的可卡因毒性影响的比较
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8
Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4.苯妥英在人肝微粒体/胞质溶胶中形成二羟基代谢物：细胞色素P450 2C9、2C19和3A4的作用。
Drug Metab Dispos. 2000 Nov;28(11):1361-8.
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Effects of phenytoin on cocaine self-administration in humans.苯妥英对人体可卡因自我给药的影响。
Drug Alcohol Depend. 1999 Feb 1;53(3):273-5. doi: 10.1016/s0376-8716(98)00140-9.
10
Phenytoin in the treatment of cocaine abuse: a double-blind study.苯妥英治疗可卡因滥用：一项双盲研究。
Clin Pharmacol Ther. 1996 Apr;59(4):458-68. doi: 10.1016/S0009-9236(96)90116-2.

因可卡因掺假导致的苯妥英中毒。

Phenytoin toxicity from cocaine adulteration.

作者信息

Roldan Carlos J

机构信息

Department of Emergency Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

出版信息

West J Emerg Med. 2014 Mar;15(2):127-30. doi: 10.5811/westjem.2013.12.20010.

DOI:10.5811/westjem.2013.12.20010
PMID:24672596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3966464/
Abstract

The use of phenytoin (PHT) as a cocaine adulterant was reported decades ago; that practice is still current. Ironically PHT has also been used for the treatment of cocaine dependence. A drug smuggler developed PHT toxicity after swallowing several rocks of crack. We investigated the current trends of PHT as a cocaine adulterant and its toxicological implications. We also reviewed the clinical use of PTH in relation to cocaine. The use of PHT as cocaine cut is a current practice. This may affect the clinical manifestations and the management of the cocaine-related visits to the emergency department.

摘要

几十年前就有关于使用苯妥英（PHT）作为可卡因掺杂物的报道；这种做法至今仍存在。具有讽刺意味的是，PHT也被用于治疗可卡因依赖。一名毒品走私者在吞下几块快克可卡因后出现了PHT中毒。我们调查了PHT作为可卡因掺杂物的当前趋势及其毒理学影响。我们还回顾了PTH与可卡因相关的临床应用。使用PHT作为可卡因的稀释剂是目前的一种做法。这可能会影响可卡因相关急诊就诊的临床表现和处理。