白细胞介素-18和白细胞介素-1β：ICE（半胱天冬酶-1）的两种细胞因子底物。
Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1).
作者信息
Fantuzzi G, Dinarello C A
机构信息
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA.
出版信息
J Clin Immunol. 1999 Jan;19(1):1-11. doi: 10.1023/a:1020506300324.
This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1 beta and the novel cytokine IL-18, which was formerly called IFN gamma-inducing factor (IGIF). The "classical" pathways of cytokine processing are described, as well as the importance of alternative cleavage enzymes. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.
这篇专题文章探讨了加工酶在生物活性细胞因子生成中的作用，特别是白细胞介素-1β（IL-1β）和新型细胞因子白细胞介素-18（IL-18），后者以前被称为干扰素γ诱导因子（IGIF）。文中描述了细胞因子加工的“经典”途径以及替代切割酶的重要性。本综述的主题还涉及IL-18的生物学特性。文中描述了IL-18产生的调节、IL-18受体复合物以及这种新型细胞因子的生物学效应。
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