细胞因子对变应性鼻炎青少年健康相关生活质量的影响。

The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis.

作者信息

Krsmanović Ljiljana, Arsović Nenad, Bokonjić Dejan, Nešić Vladimir, Dudvarski Zoran, Pavlović Dragana, Dubravac Tanasković Milena, Ristić Siniša, Elez-Burnjaković Nikolina, Balaban Radmila, Ćurčić Branislava, Ivanović Radenko, Vuković Nikolina, Vuković Maja, Milić Marija, Joksimović Bojan

机构信息

University Hospital Foča, 73300 Foča, Bosnia and Herzegovina.

Faculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and Herzegovina.

出版信息

Biomedicines. 2024 Feb 13;12(2):428. doi: 10.3390/biomedicines12020428.

DOI:10.3390/biomedicines12020428

PMID:38398030

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10886792/

Abstract

BACKGROUND

Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR.

METHODS

European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), "The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire" (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay.

RESULTS

The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β ( = 0.002), IL-6 ( = 0.031), IL-8 ( < 0.001), IL17-A ( = 0.013) and IL-18 ( = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly ( < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR.

CONCLUSIONS

This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research.

摘要

背景

鼻部症状频发是变应性鼻炎（AR）常见的临床表现（CM），对青少年的健康相关生活质量（HRQoL）有显著负面影响。这项横断面研究的目的是检验以下假设：鼻黏液中的细胞因子可能与青少年AR患者的HRQoL相关。

方法

对113例AR青少年、非变应性鼻炎（NAR）青少年及健康对照者进行欧洲生活质量五维度三级量表（EQ-5D-3L）、“青少年鼻结膜炎生活质量问卷”（AdolRQLQ）及总4症状评分（T4SS）评分系统评估。采集鼻分泌物样本，采用多重流式细胞术磁珠分析法检测13种细胞因子。

结果

与对照组相比，AR组的EQ-5D-3L得分显著更低（0.661±0.267对0.943±0.088；<0.001），AdolRQLQ总分更高（2.76±1.01对1.02±0.10；<0.001）。与对照组相比，AR组的白细胞介素-1β（IL-1β）（=0.002）、白细胞介素-6（IL-6）（=0.031）、白细胞介素-8（IL-8）（<0.001）、白细胞介素-17A（IL-17-A）（=0.013）和白细胞介素-18（IL-18）（=0.014）浓度更高，且IL-1β、IL-6、IL-17-A和IL-18随疾病进展显著升高（<0.050）。细胞因子IL-1β、IL-6以及严重的CM被确定为青少年AR患者HRQoL较低的显著预测因素。