Mamon H J, Wen P Y, Burns A C, Loeffler J S
Department of Radiation Therapy, Joint Center for Radiation Therapy, Boston, Massachusetts 02215, USA.
Epilepsia. 1999 Mar;40(3):341-4. doi: 10.1111/j.1528-1157.1999.tb00715.x.
Erythema multiforme and Stevens-Johnson syndrome have been associated with anticonvulsant medications (AEDs) in patients with brain tumors receiving cranial irradiation. AEDs are also known to cause mild drug rashes. The incidence of these complications has not been well studied among patients with brain tumors. We reviewed the records of patients with brain tumors treated with cranial radiation and AEDs to assess the frequency of both severe and mild skin reactions.
Retrospective review of 289 radiotherapy records of consecutively treated patients from 1988 to 1993.
Only one of 289 patients developed erythema multiforme. Milder rashes, however, occurred in 18% of exposures to AEDs including 22% of exposures to phenytoin, compared with the expected rate of 5-10%. Most of the mild drug rashes occurred before the initiation of radiotherapy, suggesting that radiation was not the cause of these reactions.
Severe skin rashes are rare among patients with brain tumors receiving radiation therapy and AEDs. There is, however, an increased frequency of mild drug rashes among patients with brain tumors that does not appear related to radiation.
在接受颅脑照射的脑肿瘤患者中，多形红斑和史蒂文斯-约翰逊综合征与抗惊厥药物（AEDs）有关。已知AEDs也会引起轻度药物皮疹。在脑肿瘤患者中，这些并发症的发生率尚未得到充分研究。我们回顾了接受颅脑放疗和AEDs治疗的脑肿瘤患者的记录，以评估严重和轻度皮肤反应的发生率。
回顾性分析1988年至1993年连续治疗的289例放疗记录。
289例患者中仅有1例发生多形红斑。然而，18%的AEDs暴露出现了较轻的皮疹，其中苯妥英暴露的皮疹发生率为22%，而预期发生率为5-10%。大多数轻度药物皮疹发生在放疗开始前，这表明放疗不是这些反应的原因。
在接受放疗和AEDs治疗的脑肿瘤患者中，严重皮疹很少见。然而，脑肿瘤患者中轻度药物皮疹的发生率有所增加，这似乎与放疗无关。
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