一名接受妇科近距离放射治疗的患者发生史蒂文斯-约翰逊综合征：是一种关联还是一个事件？
Stevens Johnson Syndrome in a patient undergoing gynaecological brachytherapy: An association or an incident?
作者信息
Ferreira Miguel Reis, Amado Ana, Jorge Marília, Grillo Isabel Monteiro
机构信息
Department of Radiotherapy, Hospital de Santa Maria, EPE Avenida Prof. Egas Moniz, 1649-035 Lisboa, Portugal.
出版信息
Rep Pract Oncol Radiother. 2011 Apr 8;16(3):115-7. doi: 10.1016/j.rpor.2011.02.002. eCollection 2011.
BACKGROUND
Stevens Johnson Syndrome and Erythema Multiforme are hypersensitivity skin reactions generally arising in the context of multiple causes. Radiation therapy is considered to be one of these causes, although most reports are hindered by concomitant medications.
AIM
The aim of this paper was to present a case of Stevens Johnson Syndrome arising in a patient undergoing gynaecological brachytherapy with an unusual presentation.
CASE
We describe a case of a 56-year-old woman with endometrial cancer undergoing adjuvant gynaecological radiotherapy. While undergoing a gynaecological brachytherapy boost, she developed bilateral conjunctivitis that progressed to oral mucositis and pruritic erythema with sloughing of the skin on her arms and legs but not the torso or irradiated fields (namely the vaginal mucosa).
CONCLUSION
This case illustrates the association of RT/SJS; however, it also raises the question of patients undergoing RT being more susceptible to SJS as opposed to a direct cause of the disease.
背景
史蒂文斯-约翰逊综合征（Stevens Johnson Syndrome，SJS）和多形红斑是通常由多种原因引起的超敏性皮肤反应。放射治疗被认为是其中一个原因，尽管大多数报告因同时使用的药物而受到干扰。
目的
本文旨在介绍一例在接受妇科近距离放射治疗的患者中发生的史蒂文斯-约翰逊综合征，其表现不寻常。
病例
我们描述了一例56岁患有子宫内膜癌的女性接受辅助性妇科放射治疗的病例。在接受妇科近距离放射治疗强化时，她出现了双侧结膜炎，进而发展为口腔黏膜炎和瘙痒性红斑，手臂和腿部皮肤出现脱落，但躯干或照射区域（即阴道黏膜）未出现。
结论
该病例说明了放疗与史蒂文斯-约翰逊综合征之间的关联；然而，这也引发了一个问题，即接受放疗的患者是否比该疾病的直接病因更容易患史蒂文斯-约翰逊综合征。
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