Holzhauer R J, Van Ess J D, Schwartz R H
Am J Hum Genet. 1976 Nov;28(6):602-6.
In a study of C3 levels and phenotypes in 64 cystic fibrosis (CF) patients, 92 CF parents, 64 normal siblings, and 126 healthy controls, significant elevations of mean C3 levels were found in CF patients, their parents, and in one genetic sub-group of their siblins (SS females). C3 concentration in CF patients correlated with the degree of clinical impairment as measured by Shwachman-Kulczycki (S-K) score. No significant differences were found in the prevalences of C3 phenotypes or the S and F gene frequencies among the groups studied.
在一项针对64名囊性纤维化(CF)患者、92名CF患者的父母、64名正常同胞以及126名健康对照者的C3水平和表型的研究中,发现CF患者及其父母以及其同胞的一个遗传亚组(SS女性)的平均C3水平显著升高。CF患者的C3浓度与通过施瓦赫曼 - 库尔奇茨基(S - K)评分衡量的临床损害程度相关。在所研究的各组中,C3表型的患病率或S和F基因频率未发现显著差异。