囊性纤维化中补体的第三种成分。
Third component of complement in cystic fibrosis.
作者信息
Holzhauer R J, Van Ess J D, Schwartz R H
出版信息
Am J Hum Genet. 1976 Nov;28(6):602-6.
Abstract
In a study of C3 levels and phenotypes in 64 cystic fibrosis (CF) patients, 92 CF parents, 64 normal siblings, and 126 healthy controls, significant elevations of mean C3 levels were found in CF patients, their parents, and in one genetic sub-group of their siblins (SS females). C3 concentration in CF patients correlated with the degree of clinical impairment as measured by Shwachman-Kulczycki (S-K) score. No significant differences were found in the prevalences of C3 phenotypes or the S and F gene frequencies among the groups studied.
摘要
在一项针对64名囊性纤维化（CF）患者、92名CF患者的父母、64名正常同胞以及126名健康对照者的C3水平和表型的研究中，发现CF患者及其父母以及其同胞的一个遗传亚组（SS女性）的平均C3水平显著升高。CF患者的C3浓度与通过施瓦赫曼 - 库尔奇茨基（S - K）评分衡量的临床损害程度相关。在所研究的各组中，C3表型的患病率或S和F基因频率未发现显著差异。
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本文引用的文献
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Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period.对105例囊性纤维化患者进行的长期研究；研究历时5至14年。
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Genetic polymorphism of the third component of human complement (C'3).人类补体第三成分（C'3）的基因多态性。
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High voltage agarose gel electrophoresis in the study of C 3 polymorphism.用于C3多态性研究的高压琼脂糖凝胶电泳
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