Jacobsson H, Johansson L, Kimiaei S, Larsson S A
Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.
Acta Radiol. 1999 Mar;40(2):224-8. doi: 10.3109/02841859909177744.
Normal radioactivity in the liver is often shown to be higher in the left lobe than in the right lobe at clinical examination by single photon emission computed tomography (SPECT) with 123I-metaiodobenzylguanidine (123I-MIBG). Our objective was to determine whether this represents a pathological condition.
The distribution of 123I-MIBG in the liver was retrospectively studied in clinical patients who had normal CT examinations of the liver and spleen. In the SPECT sections of 27 123I-MIBG examinations, we determined the activity ratios between the left and right lobes. The control group comprised 33 examinations with (111)In-pentetreotide (OctreoScan) and 23 examinations with 99mTc-antigranulocyte antibody.
The mean activity ratio between left and right lobes for 123I-MIBG was 1.24, and for (111)In-pentetreotide 0.87. These figures differed significantly both from each other and from 1.00. The mean ratio for 99mTc-antibody at the early examinations was 0.99, and at the late examinations 0.95. These figures differed significantly from the values for 123I-MIBG and (111)In-pentetreotide.
The increased concentration of 123I-MIBG in the left lobe of the liver compared to the right lobe is a normal finding. The reason for this cannot be explained. The difference in the way in which the left and right lobes deal with the three radiopharmaceuticals is a new finding and indicates a regional difference in liver function that has not been reported previously.
在临床检查中，通过单光子发射计算机断层扫描（SPECT）使用123I-间碘苄胍（123I-MIBG）时，肝脏的正常放射性通常显示左叶高于右叶。我们的目的是确定这是否代表一种病理状况。
回顾性研究了肝脏和脾脏CT检查正常的临床患者中123I-MIBG在肝脏中的分布情况。在27次123I-MIBG检查的SPECT切片中，我们确定了左右叶之间的活性比。对照组包括33次使用（111）In-奥曲肽（OctreoScan）的检查和23次使用99mTc-抗粒细胞抗体的检查。
123I-MIBG左右叶的平均活性比为1.24，（111）In-奥曲肽为0.87。这些数值彼此之间以及与1.00均有显著差异。99mTc-抗体早期检查的平均比值为0.99，晚期检查为0.95。这些数值与123I-MIBG和（111）In-奥曲肽的值有显著差异。
与右叶相比，肝脏左叶中123I-MIBG浓度增加是正常现象。其原因尚无法解释。左右叶处理这三种放射性药物方式的差异是一项新发现，表明肝脏功能存在尚未有报道的区域差异。
