• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用奥克太尔治疗鞭虫病。

Treatment for trichuriasis with oxantel.

作者信息

Garcia E G

出版信息

Am J Trop Med Hyg. 1976 Nov;25(6):914-5. doi: 10.4269/ajtmh.1976.25.914.

DOI:10.4269/ajtmh.1976.25.914
PMID:1008134
Abstract

Single doses of oxantel given to 24 children and 37 adults with light to moderate infections of Trichuris trichiura effected cures in 20 of 26 (77%) trials with 10 mg/kg body weight, in 23 of 25 (92%) with 15 mg/kg, and in 10 of 10 trials with 20 mg/kg. In cases not cured, the egg-counts were reduced 50% to 91%. Side effects were not observed, and no drug-associated changes were detected by biochemical, hematologic, and urine examinations before and after treatment.

摘要

对24名儿童和37名轻至中度鞭虫感染的成年人单次给予奥克太尔,在26项试验中,10mg/kg体重剂量组20例(77%)治愈,15mg/kg剂量组25例中有23例(92%)治愈,20mg/kg剂量组10项试验全部治愈。未治愈的病例中,虫卵计数减少了50%至91%。未观察到副作用,治疗前后的生化、血液学和尿液检查未发现与药物相关的变化。

相似文献

1
Treatment for trichuriasis with oxantel.用奥克太尔治疗鞭虫病。
Am J Trop Med Hyg. 1976 Nov;25(6):914-5. doi: 10.4269/ajtmh.1976.25.914.
2
Therapeutic evaluation of oxantel pamoate (1, 4, 5, 6-tetrahydro-1-methyl-2-[trans-3-hydroxystyryl] pyrimidine pamoate) in severe Trichuris trichiura infection.奥克太尔(1,4,5,6-四氢-1-甲基-2-[反式-3-羟基苯乙烯基]嘧啶双羟萘酸盐)治疗重度鞭虫感染的疗效评估
Am J Trop Med Hyg. 1976 Jul;25(4):563-7. doi: 10.4269/ajtmh.1976.25.563.
3
A comparative study of the effect of oxantel-pyrantel suspension and mebendazole in mixed infections with Ascaris and Trichuris.奥克太尔-噻嘧啶混悬液与甲苯达唑对蛔虫和鞭虫混合感染疗效的比较研究
Drugs. 1978;15 Suppl 1:94-8. doi: 10.2165/00003495-197800151-00018.
4
Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.阿苯达唑联合伊维菌素、阿苯达唑联合甲苯达唑、阿苯达唑联合奥苯达唑、甲苯达唑单独治疗鞭虫和同时感染的土壤传播性蠕虫感染的疗效和安全性:一项四臂随机对照试验。
Lancet Infect Dis. 2015 Mar;15(3):277-84. doi: 10.1016/S1473-3099(14)71050-3. Epub 2015 Jan 12.
5
Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.奥硝唑苯甲酸盐治疗坦桑尼亚奔巴岛感染鞭虫的学龄儿童的疗效和安全性:一项平行、随机、对照、剂量范围研究。
Lancet Infect Dis. 2016 Jan;16(1):53-60. doi: 10.1016/S1473-3099(15)00271-6. Epub 2015 Sep 18.
6
Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.单独使用莫昔克丁以及与阿苯达唑和三苯双脒联合用药与阿苯达唑加奥苯达唑相比治疗鞭虫感染的疗效和耐受性:一项随机、非劣效性、单盲试验。
Lancet Infect Dis. 2018 Aug;18(8):864-873. doi: 10.1016/S1473-3099(18)30233-0. Epub 2018 May 29.
7
A clinical evaluation of the efficacy of mebendazole in the treatment of trichuriasis.
South Med J. 1975 Jan;68(1):38-40. doi: 10.1097/00007611-197501000-00011.
8
Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial.在坦桑尼亚和科特迪瓦,评价三苯双脒、三苯双脒加伊维菌素、三苯双脒加奥苯达唑、阿苯达唑加奥苯达唑治疗钩虫和同时存在的土壤传播性蠕虫感染的疗效和安全性:一项随机、对照、单盲、非劣效性试验。
Lancet Infect Dis. 2017 Nov;17(11):1162-1171. doi: 10.1016/S1473-3099(17)30487-5. Epub 2017 Aug 29.
9
Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections.奥克太尔及奥克太尔-噻嘧啶对肠道线虫感染的驱虫作用
Drugs. 1978;15 Suppl 1:99-103. doi: 10.2165/00003495-197800151-00019.
10
Comment on: The impact of baseline faecal egg counts on the efficacy of single-dose albendazole against Trichuris trichiura.评论:基线粪便虫卵计数对单剂量阿苯达唑治疗鞭虫疗效的影响
Trans R Soc Trop Med Hyg. 2012 Jun;106(6):390; author reply 390-2. doi: 10.1016/j.trstmh.2012.03.008. Epub 2012 May 4.

引用本文的文献

1
Functional Characterization of the Oxantel-Sensitive Acetylcholine Receptor from .来自……的奥克太尔敏感型乙酰胆碱受体的功能特性
Pharmaceuticals (Basel). 2021 Jul 20;14(7):698. doi: 10.3390/ph14070698.
2
The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms.窄谱驱虫药奥苯达唑是鞭虫新型乙酰胆碱受体亚型的有效激动剂。
PLoS Pathog. 2021 Feb 5;17(2):e1008982. doi: 10.1371/journal.ppat.1008982. eCollection 2021 Feb.
3
A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From and .
来自[具体来源1]和[具体来源2]的同源五聚体烟碱型乙酰胆碱受体(ACR-16)的功能比较
Front Mol Neurosci. 2020 Nov 26;13:601102. doi: 10.3389/fnmol.2020.601102. eCollection 2020.
4
Repurposing drugs for the treatment and control of helminth infections.药物重新利用以治疗和控制蠕虫感染。
Int J Parasitol Drugs Drug Resist. 2014 Jul 30;4(3):185-200. doi: 10.1016/j.ijpddr.2014.07.002. eCollection 2014 Dec.
5
Oxantel disrupts polymicrobial biofilm development of periodontal pathogens.奥硝唑破坏牙周致病菌的多微生物生物膜形成。
Antimicrob Agents Chemother. 2014;58(1):378-85. doi: 10.1128/AAC.01375-13. Epub 2013 Oct 28.
6
Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug.奥硝唑单药治疗和联合化疗对鞭虫和钩虫的疗效:一种老药的复兴。
PLoS Negl Trop Dis. 2013;7(3):e2119. doi: 10.1371/journal.pntd.0002119. Epub 2013 Mar 21.
7
Inhibition of Porphyromonas gingivalis biofilm by oxantel.奥硝唑抑制牙龈卟啉单胞菌生物膜
Antimicrob Agents Chemother. 2010 Mar;54(3):1311-4. doi: 10.1128/AAC.00946-09. Epub 2009 Dec 28.
8
Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections.评价噻嘧啶-奥克太尔治疗土源性线虫感染的疗效。
Trans R Soc Trop Med Hyg. 2002 Nov-Dec;96(6):685-90. doi: 10.1016/s0035-9203(02)90352-4.
9
A comparative trial of oxantel-pyrantel and mebendazole in multiple helminth infection in school children.奥克太尔-噻嘧啶与甲苯达唑治疗学童多重蠕虫感染的比较试验。
Drugs. 1978;15 Suppl 1:73-7. doi: 10.2165/00003495-197800151-00015.
10
Treatment of multiple intestinal helminthiasis with oxantel and pyrantel.用奥克太尔和噻嘧啶治疗多重肠道蠕虫病。
Drugs. 1978;15 Suppl 1:70-2. doi: 10.2165/00003495-197800151-00014.