Lim J K
Drugs. 1978;15 Suppl 1:99-103. doi: 10.2165/00003495-197800151-00019.
704 patients with intestinal nematode infestation were treated with oxantel and oxantel-pyrantel in either liquid or tablet form, at doses from 10 to 25mg/kg. All were given the drug or drugs as a single dose. In 699 patients with trichuriasis cure rates between 64 and 93% were obtained and there were egg reduction rates of between 90 and 100%. The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. Only mild side-effects were noted. The combination, oxantel-pyrantel is a safe and effective treatment for multiple intestinal nematode infection.
704例肠道线虫感染患者接受了奥克太尔以及液体或片剂形式的奥克太尔-噻嘧啶治疗，剂量为10至25毫克/千克。所有患者均单次给药。699例鞭虫病患者的治愈率在64%至93%之间，虫卵减少率在90%至100%之间。使用奥克太尔单独或与噻嘧啶联合，剂量为15至20毫克/千克时效果最佳。152例蛔虫病患者中，单次服用10、15或20毫克/千克的噻嘧啶（以奥克太尔-噻嘧啶形式给药）后，只有2例未治愈，且这两名患者均来自最低剂量组。仅观察到轻微的副作用。奥克太尔-噻嘧啶组合是治疗多种肠道线虫感染的安全有效疗法。
