Gerdts R, Jensen D, Fauchald P, Skjeldal O
Nevrologisk avdeling, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1999 Feb 10;119(4):506-9.
The Guillain-Barré's syndrome, or acute polyradiculoneuropathy, is a monophasic neurological disease affecting 50-100 persons a year in Norway. In addition to peripheral paresis, respiratory and autonomic disturbances may occur. We present 22 patients, mean age 34.8 years, including four children between four and six years of age, who all received plasma exchange treatment. All our patients reported symptoms of a modest infection average 19 days before the neurological symptoms appeared. All patients had walking difficulties, half of them were unable to walk without assistance. There were cranial nerve findings in 18 patients, and nine had autonomic disturbances when admitted. All except one had increased protein contents in the spinal fluid as well as pathological findings in electrophysiological investigations. They received on average 8.6 plasma exchanges. In spite of such treatment, the total mortality rate has not decreased substantially. Two of our patients died, and three developed severe permanent paresis. Further studies on pathogenesis will be required to increase treatment success.
格林-巴利综合征，即急性感染性多发性神经根神经炎，是一种单相性神经系统疾病，在挪威每年影响50至100人。除周围性轻瘫外，还可能出现呼吸和自主神经功能障碍。我们报告了22例患者，平均年龄34.8岁，其中包括4名4至6岁的儿童，他们均接受了血浆置换治疗。我们所有的患者均报告在神经症状出现前平均19天有轻度感染症状。所有患者均有行走困难，其中一半患者在无辅助的情况下无法行走。18例患者有颅神经表现，9例患者入院时有自主神经功能障碍。除1例患者外，所有患者的脑脊液蛋白含量均升高，电生理检查也有病理表现。他们平均接受了8.6次血浆置换。尽管进行了这样的治疗，但总死亡率并未大幅下降。我们的2例患者死亡，3例患者出现严重的永久性轻瘫。需要进一步研究发病机制以提高治疗成功率。
