White J J, Bell W, Matthews P, Büky B
Anaesthesist. 1976 Nov;25(11):526-8.
Treatment of overwhelming but reversible respiratory failure has broadened to include extracorporeal support with a membrane lung. Until recently, it has been necessary to rely on heparin to prevent clotting in an extracorporeal circuit. During prolonged bypass heparinisation may be attended by bleeding. We investigated the use of arvin for systemic anticoagulation in extracorporeal membrane lung bypass in lambs. Arvin is a purified fraction of the venom of the Malayan pit viper. Effective anticoagulation was obtained for an average of 4 days (range 2 to 12 days) through complete fibrinogen depletion by arvin. These preliminary data suggest that arvin anticoagulation may be suitable for prolonged extracorporeal membrane oxygenation.
对于严重但可逆的呼吸衰竭的治疗已有所拓宽，包括使用膜肺进行体外支持。直到最近，一直需要依靠肝素防止体外循环中的凝血。在长时间体外循环期间，肝素化可能会伴有出血。我们研究了在羔羊体外膜肺氧合中使用抗凝血酶Ⅲ进行全身抗凝。抗凝血酶Ⅲ是马来亚蝰蛇毒液的纯化组分。通过抗凝血酶Ⅲ使纤维蛋白原完全耗竭，平均可实现4天（范围为2至12天）的有效抗凝。这些初步数据表明，抗凝血酶Ⅲ抗凝可能适用于长时间的体外膜肺氧合。
