Fossum E, Høieggen A, Moan A, Rostrup M, Kjeldsen S E
Department of Internal Medicine, Ullevaal University Hospital, Oslo,
Hypertension. 1999 Mar;33(3):781-6. doi: 10.1161/01.hyp.33.3.781.
Insulin resistance is related to physical inactivity, which is a risk factor for cardiovascular disease and death. Moreover, blood pressure responses during the first 6 minutes of an exercise test (600 kilo/pound/meter [kpm] per min) are more predictive for cardiovascular morbidity and mortality than blood pressure at rest, which could reflect that exercise blood pressure correlates more closely to peripheral structural vascular changes than casual blood pressure. We have recently shown a correlation between insulin resistance and minimal forearm vascular resistance (MFVR) in young men recruited from the highest blood pressure percentiles during a military draft session. In the present study, we tested the hypotheses that insulin sensitivity relates to physical fitness and that blood pressure responses during an exercise test relate to peripheral structural vascular changes in these men; we also tested whether these findings were interrelated. We assessed insulin sensitivity and physical fitness in 27 young men randomly selected from the cohort having a blood pressure of 140/90 mm Hg or higher during the compulsory military draft session in Oslo. Insulin sensitivity correlated with physical fitness (r=0.58, P=0.002). Systolic blood pressure after 6 minutes of exercise (600 kpm/min) correlated with MFVR (r=0.46, P=0.015). MFVR and physical fitness independently explained 60% of the variation in insulin sensitivity, and MFVR independently explained 19% of the variation of systolic blood pressure after 6 minutes of exercise. In conclusion, insulin sensitivity is related to physical fitness and exercise blood pressure to structural vascular properties in these young men.
胰岛素抵抗与身体活动不足有关，而身体活动不足是心血管疾病和死亡的一个危险因素。此外，运动测试最初6分钟（每分钟600千磅/英尺/米[kpm]）期间的血压反应比静息血压更能预测心血管疾病的发病率和死亡率，这可能反映出运动血压比日常血压与外周结构性血管变化的相关性更强。我们最近在一次征兵体检中，对来自血压最高百分位数的年轻男性进行研究，发现胰岛素抵抗与最小前臂血管阻力（MFVR）之间存在相关性。在本研究中，我们检验了以下假设：胰岛素敏感性与身体素质有关，运动测试期间的血压反应与这些男性的外周结构性血管变化有关；我们还检验了这些发现是否相互关联。我们在奥斯陆义务兵役体检期间，从血压为140/90毫米汞柱或更高的队列中随机选取了27名年轻男性，评估了他们的胰岛素敏感性和身体素质。胰岛素敏感性与身体素质相关（r = 0.58，P = 0.002）。运动6分钟（600 kpm/分钟）后的收缩压与MFVR相关（r = 0.46，P = 0.015）。MFVR和身体素质独立解释了胰岛素敏感性60%的变异，MFVR独立解释了运动6分钟后收缩压19%的变异。总之，在这些年轻男性中，胰岛素敏感性与身体素质有关，运动血压与结构性血管特性有关。
