Bartolomé M V, Vago P, Gil-Loyzaga P, Humbert G, Joubert-Caron R, Pujol R, Lenoir M
Centro Cultivos Celulares (CAI-UCM) and Departamento de Cirugía II (ORL), Facultad Medicina, Universidad Complutense, Madrid, Spain.
Brain Res. 1999 Mar 20;822(1-2):43-51. doi: 10.1016/s0006-8993(99)01070-7.
Hair cell loss and a non-functional epithelial reorganization appeared in the organ of Corti after acoustic or toxic damage. Moreover, in the drug damaged organ of Corti, transient atypical cells were recently described with characteristics of both immature hair cells and/or non-sensory epithelial cells. The phenotype of these atypical cells has been now investigated by using the galectine 1 (GAL-1) antibody. In the normal organ of Corti, this antibody recognizes all the epithelial cells except the sensory hair cells and their supporting cells. At PD 21, transient atypical cells were not stained by GAL-1 antibody, suggesting that they were originated from hair cells or their supporting cells. Later, the organ of Corti was substituted by an epithelial scare, GAL-1 stained. This study also emphasizes the particular resistance of the cochlear apex to degeneration after antibiotic intoxication.
在受到声学或毒性损伤后，柯蒂氏器中出现了毛细胞丢失和无功能的上皮重组。此外，在药物损伤的柯蒂氏器中，最近发现了具有未成熟毛细胞和/或非感觉上皮细胞特征的短暂性非典型细胞。现在已使用半乳糖凝集素1（GAL-1）抗体对这些非典型细胞的表型进行了研究。在正常的柯蒂氏器中，该抗体可识别除感觉毛细胞及其支持细胞之外的所有上皮细胞。在出生后第21天，短暂性非典型细胞未被GAL-1抗体染色，这表明它们起源于毛细胞或其支持细胞。后来，柯蒂氏器被上皮瘢痕替代，GAL-1染色。这项研究还强调了耳蜗顶端对抗生素中毒后变性的特殊抵抗力。
