Vago P, Humbert G, Lenoir M
INSERM U254 et Histologie-Embryologie-Cytogénétique, Université Montpellier I, Faculté de Médecine, CHU Hôpital Saint Charles, France.
Neuroreport. 1998 Feb 16;9(3):431-6. doi: 10.1097/00001756-199802160-00014.
Recently, an attempt at cochlear hair cell neodifferentiation has been reported in amikacin-treated rats. In the present study, we aimed to ascertain whether hair cell losses are mediated by apoptosis and whether cell proliferation occurs in damaged intoxicated cochleas. The results show that apoptosis is responsible for hair cell losses and that cell proliferation occurs in the region of the outer spiral sulcus but not in the region of Deiters cells and pre-existing hair cells. We suggest that cell proliferation maintains a certain homeostasis in the number of non-sensory cells and participates in epithelial scar formation. Neodifferentiated cells therefore probably arise from direct transdifferentiation, which could be triggered by phagocytosis of apoptotic bodies.
最近，有报道称在接受阿米卡星治疗的大鼠中尝试进行耳蜗毛细胞的新分化。在本研究中，我们旨在确定毛细胞损失是否由凋亡介导，以及在受损中毒的耳蜗中是否发生细胞增殖。结果表明，凋亡是毛细胞损失的原因，并且细胞增殖发生在外螺旋沟区域，而不是在Deiters细胞和原有毛细胞区域。我们认为细胞增殖维持了非感觉细胞数量的一定稳态，并参与上皮瘢痕形成。因此，新分化的细胞可能源于直接转分化，这可能由凋亡小体的吞噬作用触发。
