Gréen K
Prostaglandins. 1978 May;15(5):813-21. doi: 10.1016/0090-6980(78)90147-8.
This isomer of PGF2alpha is relatively resistant to metabolic degradation in the Cynomolgus monkey. Thus, 16-20 per cent of the amount injected was excreted unchanged in the urine. Five metabolites with 20, 18, 16 and 14 carbon atoms in the skeleton were identified. The data are similar to those earlier seen in the rat and further support the idea that this analogue of PGF2alpha could have a long half-life time in the mammalian body and thus a long duration of its pharmacological actions.
PGF2α的这种异构体在食蟹猴体内相对不易被代谢降解。因此，注射剂量的16% - 20%以原形经尿液排出。鉴定出了5种骨架中含有20、18、16和14个碳原子的代谢物。这些数据与早期在大鼠身上观察到的数据相似，进一步支持了这种PGF2α类似物在哺乳动物体内可能具有较长半衰期从而具有较长药理作用持续时间的观点。
