Metabolism of delta4-cis-PGF1alpha in the monkey.

This isomer of PGF2alpha is relatively resistant to metabolic degradation in the Cynomolgus monkey. Thus, 16-20 per cent of the amount injected was excreted unchanged in the urine. Five metabolites with 20, 18, 16 and 14 carbon atoms in the skeleton were identified. The data are similar to those earlier seen in the rat and further support the idea that this analogue of PGF2alpha could have a long half-life time in the mammalian body and thus a long duration of its pharmacological actions.