Velickovic Z M, Carter J M
Department of Pathology Wellington School of Medicine, Wellington Hospital, New Zealand.
Bone Marrow Transplant. 1999 Feb;23(3):291-4. doi: 10.1038/sj.bmt.1701561.
Allogeneic bone marrow transplantation is the treatment of choice for several hematological conditions. Unfortunately, for the majority (70%) of patients an HLA-matched sibling donor is not available and a matched unrelated donor must be found if they are to proceed to allogeneic transplantation. Most of the donors on international registries are of Caucasian ethnic origin. It has been recognized that patients from certain racial groups have a reduced chance of finding an unrelated donor. This study reports the feasibility of finding an unrelated donor for our local New Zealand patients of Caucasian, New Zealand Maori and Pacific Islander ethnic origin presenting with transplantable hematological conditions at a single center. The search was performed on international registries using HLA-A,B and DR typings for our patients. Six of six and five of six matches were evaluated. We have shown that Maori and Pacific Islanders have significantly lower hit rates than Caucasians when searched for 6/6 antigen matches, but there was no significant difference between the three ethnic groups in finding a 5/6 antigen matched donor. This study supports the policy of the New Zealand Bone Marrow Donor Registry in recruiting New Zealand Maori and Pacific Islanders.
异基因骨髓移植是多种血液疾病的首选治疗方法。不幸的是，大多数（70%）患者无法找到 HLA 匹配的同胞供者，若要进行异基因移植，就必须找到匹配的非亲属供者。国际骨髓库中的大多数供者为白种人。人们已经认识到，某些种族群体的患者找到非亲属供者的机会较低。本研究报告了在单一中心为患有可移植血液疾病、具有白种人、新西兰毛利人和太平洋岛民种族背景的新西兰本地患者寻找非亲属供者的可行性。利用患者的 HLA - A、B 和 DR 分型在国际骨髓库中进行搜索。对 6/6 匹配中的 6 例和 5/6 匹配中的 5 例进行了评估。我们发现，在寻找 6/6 抗原匹配供者时，毛利人和太平洋岛民的匹配成功率显著低于白种人，但在寻找 5/6 抗原匹配供者方面，这三个种族群体之间没有显著差异。本研究支持新西兰骨髓供者登记处招募新西兰毛利人和太平洋岛民的政策。
