Weiss G
Department of Internal Medicine, University Hospital, Innsbruck, Austria.
Kidney Int Suppl. 1999 Mar;69:S12-7. doi: 10.1046/j.1523-1755.1999.055suppl.69012.x.
Anemia of chronic disease (ACD) is the most frequent anemia found in hospitalized patients, often occurring in subjects suffering from chronic inflammatory disorders. The underlying diversion of iron traffic leads to a withdrawal of the metal from the sites of erythropoiesis and the circulation to the storage compartment in the reticuloendothelial system, thus resulting, at the same time, in hypoferremia and hyperferritinemia. Proinflammatory and antiinflammatory cytokines, acute-phase proteins, and radicals are prominently involved in causing these disturbances of iron homeostasis. The role of these factors, as well as the pathophysiological reasons for the development of ACD, is discussed in this review.
慢性病性贫血（ACD）是住院患者中最常见的贫血类型，常发生于患有慢性炎症性疾病的患者。铁代谢的潜在改变导致铁从红细胞生成部位和循环中转移至网状内皮系统的储存部位，从而同时导致低铁血症和高铁蛋白血症。促炎和抗炎细胞因子、急性期蛋白及自由基在导致这些铁稳态紊乱中起重要作用。本文综述将讨论这些因素的作用以及ACD发生发展的病理生理原因。
