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Indole melatonin agonists and antagonists derived by shifting the melatonin side chain from the C-3 to the N-1 or to the C-2 indole position.

作者信息

Tarzia G, Diamantini G, Spadoni G

机构信息

Istituto di Chimica Farmaceutica e Tossicologica, Università degli Studi di Urbino, Urbino, Italia.

出版信息

Biol Signals Recept. 1999 Jan-Apr;8(1-2):24-31. doi: 10.1159/000014565.

DOI:10.1159/000014565
PMID:10085459
Abstract

This article reviews our efforts in the development of indole melatonin (MLT) agonist and antagonist compounds. Evidence is presented which indicates that high-affinity melatonergic agonists were obtained by shifting the MLT amido side chain from the C-3 to the N-1 indole position. Conversely, by moving the side chain from the C-3 to the C-2 indole position it is possible to produce MLT antagonist compounds.

摘要

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