Pillai C R, Devi C U
Biochemistry and Biotechnology Division, National Institute of Communicable Diseases, Sham Nath Marg, Delhi.
J Commun Dis. 1997 Dec;29(4):355-9.
Ethyl palmitate (EP) was used as a macrophage cytotoxin. The response of P. berghei after exposing the macrophage to EP was opposite to what was seen with other agents like Silica, Antimacrophage serum and Freund's complete adjuvant. EP at dose of 5 mg and above decreased the survival period (SP), median survival day (MSD) and parasite density 24 hrs. before death (K values). Prepatent period (PP) was lower at doses 10 mg and 20 mg per day for 5 days before challenge compared to their corresponding controls. EP at a dose of 5 mg and above was found to be toxic to host, mice. EP in dosage of 3 mg per mouse administered 48 hrs. before challenge resulted in an increase in the mean survival period, survival rate (30%) and decrease in the mean parasitaemia per day when compared with the corresponding control. The interfering agents affected differently both the host and/or parasite. A proper modulation of the macrophage during the course of infection may help the host in surviving this lethal infection.
棕榈酸乙酯（EP）被用作巨噬细胞细胞毒素。将巨噬细胞暴露于EP后，伯氏疟原虫的反应与二氧化硅、抗巨噬细胞血清和弗氏完全佐剂等其他物质的情况相反。剂量为5毫克及以上的EP会缩短生存时间（SP）、中位生存天数（MSD）以及死亡前24小时的寄生虫密度（K值）。与相应对照组相比，在攻击前5天每天给予10毫克和20毫克剂量的EP，其潜伏期（PP）较短。发现剂量为5毫克及以上的EP对宿主小鼠有毒性。在攻击前48小时给每只小鼠注射3毫克剂量的EP，与相应对照组相比，平均生存时间增加、生存率提高（30%）且每天的平均寄生虫血症降低。干扰剂对宿主和/或寄生虫的影响不同。在感染过程中对巨噬细胞进行适当调节可能有助于宿主在这种致命感染中存活。
