Pillai C R, Singh N N
Malaria Research Centre, Delhi, India.
Indian J Malariol. 1993 Mar;30(1):23-8.
The role of macrophages in immunogenic mechanisms of malaria was studied. The first part of the study aimed at development of indicators for assessing immunobioassay. Accordingly, data on the natural course of lethal Plasmodium berghei infection in mice were collected, and baseline estimates of a set of indicators were made. The indicators along with their estimated means are: prepatent period (PP), 2.57 +/- 0.06 days; survival period (SP), 17.63 +/- 0.29 days; median survival day (MSD), 17.20 days; and parasite density 24 h before death (K), 3582.6 infected RBC/10(4)RBCs. The probable role of immunogenic mechanisms judged indirectly by course of parasitaemia in different phases is discussed.
研究了巨噬细胞在疟疾免疫机制中的作用。该研究的第一部分旨在开发评估免疫生物测定的指标。因此，收集了小鼠感染致死性伯氏疟原虫自然病程的数据，并对一组指标进行了基线估计。这些指标及其估计均值如下：潜隐期（PP），2.57±0.06天；生存期（SP），17.63±0.29天；中位生存期（MSD），17.20天；死亡前24小时的寄生虫密度（K），3582.6个感染红细胞/10⁴个红细胞。讨论了通过不同阶段的寄生虫血症病程间接判断的免疫机制的可能作用。
