Shamelian S O, Nortier J W
Diakonessenhuis, afd. Interne Geneeskunde, Utrecht.
Ned Tijdschr Geneeskd. 1999 Jan 30;143(5):225-8.
Three patients, females aged 62, 67 and 32 years, were presented with fever and sore throat and had severe agranulocytosis (granulocyte count < 100/microliter). All had Graves' disease and were being treated with thiamazole 30 mg once a day. Thiamazole was discontinued and treatment with antibiotics initiated. None of the patients received granulocyte-colony stimulating factor (G-CSF). The mean recovery time of granulocytes was 9 days and there were no fatalities. Patients who receive antithyroid agents should be warned against the serious and potentially lethal side effect of agranulocytosis.
三名女性患者，年龄分别为62岁、67岁和32岁，出现发热和咽痛，并有严重的粒细胞缺乏症（粒细胞计数<100/微升）。她们均患有格雷夫斯病，正在接受每天一次30毫克甲巯咪唑的治疗。停用甲巯咪唑并开始使用抗生素治疗。所有患者均未接受粒细胞集落刺激因子（G-CSF）治疗。粒细胞的平均恢复时间为9天，且无死亡病例。接受抗甲状腺药物治疗的患者应被告知粒细胞缺乏症这种严重且可能致命的副作用。
