非结核分枝杆菌感染中禽类和人类结核菌素皮肤试验的差异
Differential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection.
作者信息
Daley A J, Isaacs D
机构信息
Department of Immunology and Infectious Diseases, Royal Alexandra Hospital for Children, Westmead, NSW 2145, Australia.
出版信息
Arch Dis Child. 1999 Apr;80(4):377-9. doi: 10.1136/adc.80.4.377.
OBJECTIVE
To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis.
METHOD
Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differential avian and human skin testing performed over a 10 year period from 1986 to 1996.
RESULTS
One hundred and twenty four patients had non-tuberculous mycobacteria isolated from lymph nodes over this period, 59 of whom had differential skin testing performed. The sensitivity of a response of >/= 10 mm to the avian precipitin was 58 of 59. No patient had both a negative human and avian Mantoux. The sensitivity of the human Mantoux alone for diagnosing non-tuberculous mycobacterial infection was 81% for a response of >/= 5 mm and 66% for >/= 10 mm. Ten patients had a 0 human response. Fifty five of the 59 patients had an avian response at least 2 mm greater than the human response.
CONCLUSION
The avian Mantoux is a very sensitive method of diagnosing non-tuberculous mycobacterial infection in children. The human Mantoux is not sensitive enough to be used alone as a surrogate to diagnose non-tuberculous mycobacterial infection.
目的
确定禽源和人源迟发型超敏皮肤试验在非结核分枝杆菌淋巴结炎诊断中的敏感性。
方法
回顾性分析1986年至1996年10年间所有经培养证实为非结核分枝杆菌淋巴结感染且进行了禽源和人源皮肤试验鉴别的患者。
结果
在此期间，124例患者的淋巴结中分离出非结核分枝杆菌，其中59例进行了皮肤试验鉴别。对禽源沉淀素反应≥10 mm的敏感性为59例中的58例。无人源和禽源结核菌素试验均为阴性的患者。仅人源结核菌素试验诊断非结核分枝杆菌感染时，反应≥5 mm的敏感性为81%，≥10 mm的敏感性为66%。10例患者人源反应为0。59例患者中有55例禽源反应比人源反应至少大2 mm。
结论
禽源结核菌素试验是诊断儿童非结核分枝杆菌感染的一种非常敏感的方法。人源结核菌素试验单独作为诊断非结核分枝杆菌感染的替代方法敏感性不够。
Zotero 插件