Takano H, Suzuki H
Department of Physiology, Nagoya City University Medical School, Nagoya,
Pharmacology. 1999 May;58(5):236-45. doi: 10.1159/000028286.
Junctional transmissions and their modulation by DQ-2511, a novel prokinetic agent, were investigated in smooth muscle of the guinea pig duodenum. Transmural nerve stimulation evoked a cholinergic excitatory junction potential, a nonadrenergic, noncholinergic inhibitory junction potential, and a substance P mediated slow depolarization. DQ-2511 showed dual effects on the slow depolarization: a low concentration (10(-9) mol/l) enhanced and high concentrations (>10(-6) mol/l) tended to inhibit. The depolarization produced by exogenously applied substance P was enhanced by low concentrations of DQ-2511. The results suggest that the prokinetic actions of DQ-2511 involve an enhancement of transmission from substance P neurons due to an increase in sensitivity of postjunctional receptors to substance P.
研究了新型促动力剂DQ - 2511对豚鼠十二指肠平滑肌的结间传递及其调节作用。透壁神经刺激诱发胆碱能兴奋性结电位、非肾上腺素能、非胆碱能抑制性结电位以及P物质介导的缓慢去极化。DQ - 2511对缓慢去极化表现出双重作用：低浓度（10^(-9) mol/L）增强，高浓度（>10^(-6) mol/L）则趋于抑制。低浓度的DQ - 2511可增强外源性应用P物质所产生的去极化。结果表明，DQ - 2511的促动力作用涉及由于节后受体对P物质敏感性增加而增强了P物质神经元的传递。
