新型促动力剂DQ - 2511对豚鼠胃平滑肌电活动的影响。

Effects of DQ-2511, a novel prokinetic agent, on electrical activities of smooth muscle in the guinea pig stomach.

作者信息

Imaeda K, Hashitani H, Xue L, Yamamoto Y, Itoh M, Suzuki H

机构信息

Department of Physiology, Nagoya City University Medical School, Nagoya, Japan.

出版信息

Pharmacology. 1997 Sep;55(3):144-53. doi: 10.1159/000139522.

DOI:10.1159/000139522

PMID:9346403

Abstract

Electrophysiological experiments were carried out to investigate the prokinetic actions of DQ-2511 on isolated smooth muscle of the guinea pig stomach. DQ-2511 enhanced the myogenic gastric slow waves and cholinergic excitatory junction potential and reduced the frequency of slow waves and the nonadrenergic, noncholinergic, and nonnitrergic inhibitory junction potential, with no significant alteration of the resting membrane potential. The results suggest that the prokinetic actions of DQ-2511 involve excitatory actions directly on smooth muscle and indirectly on cholinergic transmission.

摘要

进行电生理实验以研究DQ - 2511对豚鼠胃离体平滑肌的促动力作用。DQ - 2511增强了肌源性胃慢波和胆碱能兴奋性接头电位，并降低了慢波频率以及去甲肾上腺素能、胆碱能和非一氧化氮能抑制性接头电位，静息膜电位无明显改变。结果表明，DQ - 2511的促动力作用涉及直接对平滑肌的兴奋作用以及间接对胆碱能传递的兴奋作用。