Huhn F O, Stock G
Beitr Pathol. 1976 Nov;159(2):186-94.
A report is presented on the demonstration of epithelioid cell clusters within the axillary lymph node group, which - in the absence of knowledge of their structural peculiarities--could be taken for micrometastases of a solid mammary carcinoma. The lymph node material from 400 extensively excised mammary carcinomas with obligatory lymphonodectomy was available for this study. Microscopic inspection of successive sections at intervals of 100 mu was performed following fixation and optical demonstration of all lymph nodes in a picric acid medium. This procedure led to the discovery of epithelioid cell clusters in 18 out of the 400 cases examined. As regards their appearance, with direct allocation to the local vascular stroma, these clusters must be regarded as glomus-like structures. In no case could metastases of a mammary carcinoma and the epithelioid cell foci mentioned here be demonstrated either next to each other or combined. In appearance they are remarkably similar to the already known glomus structures of other sites. The presence of such structure in lymph nodes is most likely attributable to micromorphous malformation of vessels in the sense of hamartia. From a clinical point of view, their fundamental significance consists in the necessary differentialdiagnostic demarcation against metastase of solid carcinoma in the region of origin of the lymph.
本文报道了在腋窝淋巴结组中发现上皮样细胞簇的情况。在不了解其结构特点的情况下，这些细胞簇可能会被误认为是实性乳腺癌的微转移灶。本研究使用了400例广泛切除的乳腺癌并进行了必要的淋巴结清扫所获得的淋巴结材料。将所有淋巴结在苦味酸介质中固定并进行光学显示后，以100微米的间隔对连续切片进行显微镜检查。在400例检查病例中，有18例发现了上皮样细胞簇。就其外观而言，这些细胞簇直接与局部血管基质相连，必须被视为类似球样的结构。在任何情况下，都未发现乳腺癌转移灶与此处提到的上皮样细胞灶相邻或合并存在。从外观上看，它们与其他部位已知的球样结构非常相似。淋巴结中出现这种结构很可能是由于血管在错构瘤意义上的微形态畸形所致。从临床角度来看，其根本意义在于必须与淋巴起源部位的实性癌转移进行鉴别诊断。
