Mulligan Anna Marie, O'Malley Frances P
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and the University of Toronto, Toronto, Ontario, Canada.
Int J Surg Pathol. 2007 Apr;15(2):143-7. doi: 10.1177/1066896906299119.
Intracystic papillary carcinoma of the breast has rarely been reported to be associated with metastases. Presented are 2 cases, both of which showed micrometastatic carcinoma in axillary lymph nodes; neither demonstrated stromal invasion. Nearly complete absence of a myoepithelial cell layer around the periphery of the lesions was noted. One case showed 3 separate foci of micrometastatic carcinoma in 1 of 3 sentinel lymph nodes; the second showed micrometastases in 2 of 11 axillary lymph nodes. The clinical significance of micrometastases in lymph nodes associated with intracystic papillary carcinoma is unknown. The term encapsulated papillary carcinoma has been proposed to name papillary carcinomas that are surrounded by a fibrous rim, but which show a scant or absent myoepithelial cell component. The current 2 cases offer evidence to support the use of this term for particularly large encysted lesions. Sentinel lymph node biopsy may be prudent in such cases.
乳腺囊内乳头状癌很少有发生转移的报道。本文报告2例，均在腋窝淋巴结发现微转移癌；均未显示间质浸润。注意到病变周边几乎完全没有肌上皮细胞层。1例在3个前哨淋巴结中的1个发现3个独立的微转移癌灶；另1例在11个腋窝淋巴结中的2个发现微转移。与囊内乳头状癌相关的淋巴结微转移的临床意义尚不清楚。有人提出用“包膜内乳头状癌”这一术语来命名被纤维边缘包绕但肌上皮细胞成分稀少或缺乏的乳头状癌。目前这2例为支持对特别大的包囊性病变使用该术语提供了证据。在这种情况下，前哨淋巴结活检可能是谨慎的做法。
